I just got a new 10-hole pentabender (no slide) from Seydel. It is in C, but its low note is D, so that I get two full octaves in 10 holes:
D F G A C D F G A C (blow)
E G A B D E G A B D (draw)
I am planning to concentrate on learning to play it in 3rd minor position (Dm) and 2nd major position (G), two scales in which one can take advantage of the pentatonic scales on the blows and draws. (This is a very different approach from my first time trying the pentabender, back in 2014, when I mainly played it in first position.)
For learning the instrument, I plan to let the default choice in each pair of enharmonic notes be the blow note. Of the 12 notes in the chromatic scale, 7 of them have to be played as draws on the pentabender (5 as draw bends and 2 as straight draw notes), but only 2 notes have to be played as blows. So a general rule of playing the blow note in each of the 3 enharmonic pairs could be good for balancing the two breath directions.
With this convention, the C-pentabender feels very much like a C-fourkey, except that the draw notes in holes 2, 3, 5, 7, and 8 all need to be bent. For the blues, this feels very natural to me.